Coccidiosis is a common disease that affects the intestinal health of poultry worldwide. Susceptible animals exposed to Eimeria strains through fecal-oral transfer develop intestinal lesions that result in low weight gain, poor feed conversion, and mortality. Treatment with anticoccidial drugs has led to resistant strains of Eimeria and vaccination is now the preferred method for prevention. Vaccines elicit a pathogen-specific immune response that protects the animals against further parasitic challenge. Proliferation of these vaccines in live chickens poses a significant cost and a concerning animal welfare issue.
球蟲病是一種影響全球家禽腸道健康的常見疾病。通過糞 - 口轉(zhuǎn)移暴露于艾美球蟲菌株的易感動(dòng)物會(huì)發(fā)生腸道病變，導(dǎo)致體重增加低，飼料轉(zhuǎn)化率低和死亡率低。用抗球蟲藥物治療已導(dǎo)致艾美球蟲的抗性菌株，并且疫苗接種現(xiàn)在是預(yù)防的優(yōu)選方法。疫苗引發(fā)病原體特異性免疫反應(yīng)，保護(hù)動(dòng)物免受進(jìn)一步的寄生蟲攻擊。這些疫苗在活雞中的增殖造成了巨大的成本和涉及動(dòng)物福利的問題。
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